Roundup: Scientific Research

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Researcher: Ariana Arce​

Researcher: Ariana Arce​

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Journalist: Aaron Vivanco

Journalist: Aaron Vivanco

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Editor: Daniela Polo

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Roundup: Scientific Research

“Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study”

  • Published: January 11, 2023
  • A new study published in the Journal of the National Cancer Institute presented further evidence of increased cancer risk in chronic glyphosate exposure (the chemical in Roundup).
  • The study included 268 farmers with occupational glyphosate exposure and compared their health histories to non-farmers without exposure.
  • Associations between urinary glyphosate concentrations and self-reported occupational use of glyphosate were evaluated.
  • Specific oxidative stress biomarkers, 0which are known to increase cancer risk, were significantly higher in the group with glyphosate exposure.
  • Source

“Perinatal exposure to a glyphosate pesticide formulation induces offspring liver damage

  • Published: September 16, 2022
  • A new study published in the Journal of Toxicology and Applied Pharmacology revealed that prenatal or perinatal exposure to glyphosate (the active ingredient in Roundup) can trigger an iron overload and cause permanent offspring liver damage.
  • Pregnant Wistar rats were exposed to glyphosate in drinking water from day 5 of gestation to day 15 postnatal.
  • The perinatal exposure to glyphosate increased the enzymatic activities of transaminases and gamma-glutamyl transferase in the offspring’s liver and blood, suggesting a pesticide-induced liver injury.
  • Moreover, the study detected increased iron levels in the liver, blood, and bone marrow of glyphosate-exposed rats, which were accompanied by increased transferrin saturation and decreased transferrin levels in the blood.
  • Source

“CDC finds a weed killer tied to cancer in over 80% of US urine samples”

  • Published: June 30, 2022 
  • More than 80% of urine samples drawn from children and adults participating in a United States (US) health study contained a weed-killing chemical linked to cancer and other health problems.
  • The Centers for Disease Control and Prevention (CDC) reported 1,885 out of 2,310 urine samples collected were laced with detectable traces of glyphosate, which is an active ingredient in herbicides sold worldwide, including the widely used Roundup brand.
  • The study included participants representative of the US population, with approximately one-third of participants being children aged 6 and older.
  • Source

“Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence”

  • The broad scientific analysis of the cancer-causing potential of glyphosate herbicides revealed that people with high exposures to glyphosate, which is a popular pesticide, have a 41% increased risk of developing a type of cancer called non-Hodgkin lymphoma.
  • The study conducted a new meta-analysis that includes the most recent update of the Agricultural Health Study (AHS) cohort published in 2018 along with five case-control studies.
  • The findings by five United States (US) scientists contradict the US Environmental Protection Agency’s (EPA) assurances of safety over the weed killer.
  • Source

“Thyroid Cancer and Pesticide Use in a Central California Agricultural Area: A Case-Control Study”

  • Published: July 26, 2022
  • The study by a team from UCLA was published in The Journal of Clinical Endocrinology & Metabolism have linked glyphosate exposure to an increased risk of thyroid cancer.
  • The sample included 2067 cases and 1003 controls.
  • Of the 29 selected pesticides, 10 were associated with thyroid cancer, including several of the most applied pesticides in the United States such as paraquat dichloride, glyphosate, and oxyfluorfen.
  • The risk of thyroid cancer proportionately increased to the total number of participants exposed to pesticides 20 years before diagnosis or interview. In all models, paraquat dichloride was associated with thyroid cancer.
  • Source

“ARC Monograph on Glyphosate”

  • The study revealed “sufficient evidence” that glyphosate causes cancer in animals as well as damaging effects on human cells.
  • The 2015 International Agency for Research on Cancer (IARC) decided to reclassify the compound as Category 2A (probably carcinogenic to humans), marking a shift in the scientific community’s consensus view.
  • The IARC Monograph evaluation is based on the systematic assembly and review of all publicly available and pertinent studies by independent experts and is free from vested interests.
  • Therefore, IARC reviewed approximately 1000 studies to reach these conclusions. Some of the studies evaluated people exposed through their jobs, such as farmers. Others were experimental studies on cancer and cancer-related effects in experimental systems.
  • Source

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